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David J. Mogul,
Ph.D.
Associate Professor
Pritzker Institute of Biomedical Science and Engineering
Illinois Institute of Technology
10 West 32nd Street
Engineering 1, Rm 116
Chicago, IL 60616-3793
Phone : 312-567-3873
Fax : 312-567-5707
Email: mogul@iit.edu
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EDUCATION:
B.S., Electrical Engineering, Cornell University
M.S., Electrical Engineering/Computer Science, Northwestern University
Ph.D., Electrical Engineering/Computer Science, Northwestern University
Postdoctoral Fellow, Pharmacology & Physiology, University of Chicago
Research Interests:
My research can be summarized as the study of the
electrophysiology and electrical dynamics of the brain. My laboratory
has applied a quantitative approach toward understanding neuronal physiology
using both conventional and novel experimental techniques at the cellular
and systems levels. The specific part of the brain that my laboratory
has been predominantly investigating has been the hippocampus, a small
organ in the limbic region that is essential for learning and long-term
memory formation and which is a major focal site for the etiology of
a number of pathological conditions such as epilepsy and Alzheimer's
disease. More specifically, we have been engaged in studying a wide
variety of related phenomena in this region including membrane biophysics,
plasticity of neurotransmission, and nonlinear network characteristics
underlying normal and diseased behavior.
Selected Publications in Peer-Reviewed Journals:
MOGUL, D.J. & A.P. Fox. Evidence for multiple types of Ca2+ channels
in acutely isolated hippocampal CA3 neurones. J. Physiol.(Lond.) 433:
259-281, 1991.
Artalejo, C.R., D.J. MOGUL, R. Perlman, & A.P. Fox. Three types
of bovine chromaffin cell Ca2+ channels: Facilitation increases the
opening probability of a 27 pS channel. J. Physiol. (Lond.) 444: 213-240,
1991
MOGUL, D.J., M.E. Adams, & A.P. Fox. Differential activation of
adenosine receptors decreases N-type but potentiates P-type Ca current
in hippocampal CA3 neurons. Neuron. 10: 327-334, 1993.
Dave, S. & D.J. MOGUL. ATP receptor activation potentiates a voltage-dependent
Ca channel in hippocampal neurons. Brain Res. 715: 208-216, 1996.
Disterhoft, J.F., L.T. Thompson, J.R. Moyer, & D.J. MOGUL. Calcium-dependent
afterhyperpolarization and learning in young and aging hippocampus Life
Sci. 59: 413-420, 1996.
Kessey, K., B.L. Trommer, L. Overstreet, T. Ji & D.J. MOGUL. A role
for adenosine A2 receptors in the induction of long-term potentiation
in the CA1 region of rat hippocampus. Brain Res. 756: 184-190, 1997.
Fleming K.M. & D.J. MOGUL. Adenosine A3 receptors potentiate hippocampal
calcium current by a PKA-dependent/PKC-independent pathway. Neuropharmacology.
36: 353-362, 1997.
Kessey, K. & D.J. MOGUL. NMDA independent LTP by adenosine A2 receptor-mediated
postsynaptic AMPA potentiation in hippocampus. J. Neurophysiol. 78:
1965-1972, 1997.
Kessey, K. & D.J. MOGUL. Adenosine A2 receptors modulate hippocampal
synaptic transmission via a cAMP-dependent pathway. Neuroscience. 84:
59-69, 1998.
Slutzky, M.W., Cvitanovic,
P., & D.J. MOGUL. Deterministic
chaos and noise in three in vitro hippocampal models of epilepsy.
Annals of Biomedical Engineering 29:7-13, 2001.
Slutzky,
M.W., Cvitanovic, P., & D.J. MOGUL. Identification of determinism
in noisy neuronal systems. Journal of Neuroscience Methods.118: 153-161,
2002.
Slutzky,
M.W., Cvitanovic, P., & D.J. MOGUL. Manipulating
epileptiform bursting in the rat hippocampus using chaos control and
adaptive techniques. IEEE Transactions on Biomedical Engineering.
50: 559-570, 2003.
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